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    DR. LEONOR HUERTA

    Education:

    • 2004 – Doctorate in Basic Biomedical Research
    • 1992 – Research stay, Molecular Biology Laboratory of the AIDS Research Center, Duke University.
    • 1991 – Master of Chemical Sciences (Biochemistry), UNAM.

    Academic appointments:

    • Full-time Senior Researcher A, Department of Immunology, Institute of Biomedical Research, UNAM.
    • National System of Researchers, Level I.

    Research interests:

    • Properties of HIV-1 envelope proteins and their biological effects.
    • Fusion of cells of the immune system induced by HIV-1.
    • Participation of autoantibodies in the inhibition of cell fusion induced by viral proteins.
    • Inhibition by synthetic and natural compounds of infection in vitro.
    • Mathematical models of the immune response.
    • Immune response to SARS-Cov-2.

    Research interests:

    • DGAPA-PAPIIT UNAM group project IG200623. “Theoretical and experimental analysis of SARS-Cov-2 infection.
    • DGAPA/PAPIIT UNAM Project “Role of autoantibodies in the inhibition of membrane fusion induced by HIV-1”.
    • DGAPA-PAPIIT UNAM Project: “HIV infectivity of collaterally activated CD4+ T lymphocytes”.
    • CONACYT project. Call for Basic Science 2014: “Identification of antigens associated with the production of antibodies that inhibit membrane fusion induced by HIV-1”.
    • DGAPA-PAPIIT UNAM Project: “Fusion of cells of the immune system induced by the Human Immunodeficiency Virus: immunological and virological implications”.
    • CONACYT project CB-2010/152946. Call for Basic Science 2010: “Immunological and pathogenic potential of cell fusion induced by the human immunodeficiency virus type 1 (HIV-1)”.

    SELECTED PUBLICATIONS

    Soluble factors from TLR4- or TCR-activated cells contribute to the stability of the resting phenotype and increase the expression of CXCR4 of human memory CD4 T cells. Immunologic Research, 2022. Aceptado.

    David Martínez-Méndez, Leonor Huerta, Carlos Villarreal. Modeling the effect of microenvironmental nutrient conditions and hypoxia on T cell differentiation. Frontiers in Immunology, 13. 2022. DOI=10.3389/fimmu.2022.962175

    Dolores Adriana Ayón-Núñez, Jacquelynne Cervantes-Torres, Carlos Cabello-Gutiérrez, Sergio Rosales-Mendoza, Diana Rios-Valencia, Leonor Huerta, Raúl J. Bobes, Julio César Carrero, René Segura-Velázquez, Nora Alma Fierro, Marisela Hernández, Joaquín Zúñiga-Ramos, Gerardo Gamba, Graciela Cárdenas, Emanuel Frías-Jiménez, Luis Alonso Herrera, Gladis Fragoso, Edda Sciutto, Francisco Suárez-Güemes, Juan Pedro Laclette. An RBD-based diagnostic method useful for the surveillance of protective immunity against SARS-CoV-2 in the population.
    Diagnostics, 2022, 12(7), 1629. DOI: 10.3390/diagnostics12071629.

    Cárdenas G, Chávez-Canales M, Espinosa AM, Jordán-Ríos A, Malagon DA, Murillo MFM, Araujo LVT, Campos RLB, Wong-Chew RM, González LER, Cresencio KI, Velázquez EG, de la Cerda MR, Leyva Y, Hernández-Ruiz J, Hernández-Medel ML, León-Hernández M, Quero KM, Monciváis AS, Díaz SH, Martínez IRZ, Martínez-Cuazitl A, Salazar INM, Sarmiento EB, Peña AF, Hernández PS, Reynoso RIA, Reyes DM, Del Río Ambriz LR, Bonilla RAA, Cruz J, Huerta L, Fierro NA, Hernández M, Pérez-Tapia M, Meneses G, Espíndola-Arriaga E, Rosas G, Chinney A, Mendoza SR, Hernández-Aceves JA, Cervantes-Torres J, Rodríguez AF, Alor RO, Francisco SO, Salazar EA, Besedovsky H, Romano MC, Bobes RJ, Jung H, Soldevila G, López-Alvarenga J, Fragoso G, Laclette JP, Sciutto E. Intranasal dexamethasone: a new clinical trial for the control of inflammation and neuroinflammation in COVID-19 patients. Trials, 2022, 23, 148-151. DOI: 10.1186/s13063-022-06075-5.

    David Martínez-Méndez, Luis Mendoza, Carlos Villarreal, Leonor Huerta. Continuous modeling of T CD4 cell activation and function. Frontiers in Immunology, 2021, 12: 4424-4439. DOI: 10.3389/fimmu.2021.743559.

    Mirna Berenice Ruiz-Rivera, Guillermo Gómez-Icazbalceta, Leonor Huerta. Host-membrane proteins in the HIV-1-induced membrane fusion; role in pathogenesis and therapeutic potential of autoantibodies. Current Opinion in Pharmacology, 2021, 60:241-248. DOI: 10.1016/j.coph.2021.07.005.

    Karen Lizbeh Reyes-Barrera, Ruth Elena Soria-Guerra, Rogelio López-Martínez, Leonor Huerta, Nohemí Salinas-Jazmín, Carlos Cabello-Gutiérrez, Ángel Gabriel Alpuche-Solís. The entry blocker peptide produced in Chlamydomonas reinhardtii inhibits influenza viral replication in vitro. Frontiers in Plant Science, 2021, 12: 641420. DOI: 10.3389/fpls.2021.641420.

    Juan Voutssas-Lara, Jacquelynne Cervantes-Torres, Marisela Hernández, Raúl J. Bobes, Edmundo Lamoyi, Ricardo A. Vázquez-Ramírez, Luis Mendoza, Karen L. Reyes-Barrera, Rogelio López-Martínez, Angel G. Alpuche-Solís, Sergio Rosales-Mendoza, Leonor Huerta, Gladis Fragoso, Edda Sciutto. Influence of adjuvants on the amount, specificity and functional activity of antibody response to human influenza vaccine in mice. Molecular Immunology, 2021, 135: 398-407. DOI: 10.1016/j.molimm.2021.05.003.

    Leonor Huerta. Editorial: Anti-infective 2020: HIV, from pathogenesis to treatment. Current Opinion in Pharmacology, 2020, 54: x-xii. DOI: 10.1016/j.coph.2020.12.001.

    Martínez-Méndez David, Villarreal Carlos, Mendoza Luis, Huerta Leonor. An Integrative Network Modeling Approach to T CD4 Cell Activation. Frontiers in Physiology, 2020, 11, article 380: 1-14. DOI: 10.3389/fphys.2020.00380.

    Mirna Berenice Ruiz-Rivera, Guillermo Gómez-Icazbalceta, Marcela Vélez-Alavez, Mónica Viveros-Rogel, Santiago Pérez-Patrigeon, Edmundo Lamoyi, Luis Llorente, Carlos A Núñez-Álvarez, Leonor Huerta. Inhibition of the HIV-1 envelope-dependent membrane fusion by serum anti-lymphocyte autoantibodies associates with low plasma viral load. Immunology Letters 2019, 211:33-40. DOI: 10.1016/j.imlet.2019.05.002.